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This household incorporates just one protein, SET7/9, which mono-methylates histone at H3K4 ninety two KMT7 was discovered to methylate, in addition to histone, a lot of non-histone proteins, together with p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear issue kappaB (NFκB), and parts of the TATA binding protein (TBP) complex, TBP-associated components TAF10 and TAF7 ninety three The consensus recognition sequence in substrates for SET7-mediated lysine methylation, Okay/R-S/T-K (goal lysine is bold), can be acknowledged by the H3K4 demethylase KDM1A/LSD1, which is capable of removing the methyl mark on most of those substrates 17 , 94 Therefore KMT7/KDM1A has emerged as a traditional mannequin for dynamic lysine methylation of both histone and [non-histone proteins](https://thebigme.cc3000/felipa51t59125/ophelia1995/wiki/Selling-A-House). |