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These tails are topic to several put up-translational covalent modifications, including acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ).
The exception to the rule is the DOT1 family, members of which methylate K79 in the globular region of histone H3 and that are structurally not related to SET-domain proteins 4 - 6 Current work means that SET-area-containing proteins methylate a couple of proteins along with histones (see later)
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