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The exception to the rule is the DOT1 household, members of which methylate K79 within the globular area of histone H3 and that are structurally not associated to [SET-area proteins](https://git.usot.top/quyenv7916503/solicitor-uk2006/wiki/Pediatric+Cough+And+Chilly+Drug+Overdoses) 4 - 6 Recent work means that SET-domain-containing proteins methylate a couple of proteins along with histones (see later)
