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SPOT synthesis will not be restricted to proteinogenic amino acids, a number of commercially obtainable modified amino acids also can be used for synthesis, permitting peptides to be modified before and after the ultimate cleavage of the aspect-chain protection group and, moreover, it also allows incorporation of phosphorylated, methylated or acetylated amino acids eleven.

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A protein sequence alignment of the SET domains of a number of consultant histone lysine methyltransferases (HKMT) grouped in accordance with their histone-lysine specificity.

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